Blog > JellaGel™ a next-generation alternative to Matrigel®

JellaGel™ a next-generation alternative to Matrigel®


Corning® Matrigel® is the most widely used extracellular matrix (ECM) on the market. It does though, have limitations with both composition, usability, and most recently global supply issues.

Jellagen developed JellaGel to offer a viable alternative to Matrigel and in this article, we will compare the two.

Introduction to Matrigel®

Corning Matrigel™ has been commercially available for licensing through the National Institutes of Health Technology Transfer Office since 1984 and has been used for cellular applications since then. As it is the most widely used ECM for cell culture applications it has a wealth of publications through multiple applications, making it widely trusted within the field.

It consists of a reconstituted basement membrane preparation that is extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumor rich in extracellular matrix proteins. This material, once isolated, is approximately 60% laminin, 30% collagen IV, and 8% entactin.

Introduction to JellaGel™

JellaGel™ is a Next Generation Collagen Type 0 Hydrogel for in vitro cell culture and tissue engineering, offering customers a natural, non-mammalian and easy-to-use alternative to mammalian and synthetic hydrogels that are currently on the market.

It is manufactured using Collagen Type 0, an evolutionary ancient collagen, 600 million years in the making. Collagen Type 0 is derived from responsibly sourced jellyfish making it biochemically simple and naturally universal, allowing greater flexibility across multiple applications.​ Unlike alternative collagens where the “type” is specific to the end application, Collagen Type 0 is not, due to its evolutionary lineage. For this reason, it can be classed as the “stem of all collagens”.​

Jellagel has several key differences over Matrigel, which are highlighted in the table below.

JellaGel & Matrigel: the key differences

JellaGel vs Matrigel


JellaGel provides customers with a biochemically simple, consistent, and easy-to-use hydrogel that can transform their research. One of the greatest features of JellaGel is that it can be used at room temperature meaning there is no need for ice or cold rooms, unlike some hydrogels currently on the market.

This product is conveniently supplied in kit format with JellaGel solution, buffer and crosslinker for ease of use. We are now offering 5ml sample sized JellaGel kits allowing you to fully test the product at a lower price than the standard 10ml kit.


Product numbers

-JGEL5ML (Sample)



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