Vocal Cord Paralysis (VCP)
Vocal Cord paralysis is the inability to move the muscles that control the vocal cords and is caused by injury to one or both recurrent laryngeal nerves (RLNs), which control most of the muscles of the larynx. The RLN is important for speaking, breathing and swallowing. Vocal Cord Paralysis occurs when the nerve impulses of the larynx are disrupted. This results in paralysis of the vocal cord muscles.
Preferrable first-line treatments are bulking injections currently comprising either hyaluronic acid, hydroxyapatite, silk or carboxymethylcellulose. Such products (used during injection laryngoscopy, IL) face numerous challenges such as longevity in situ, medialization / phonation, immunogenicity, batch to batch consistency, disease/prion transfer, reinnervation & tissue regeneration.
Historically, such bulk filler treatments have solely focused on medialization (i.e. vocal fold bulking), however, some fillers lead to denervation; extensive muscle atrophy and degeneration replacing healthy muscle with fibrous/adipose tissue.
Our solution is a Collagen Type 0 bulk filler that can be used for IL that has shown compelling medical benefits over current treatments(San Marina. S., et al. Laryngoscope 2021). In this study, Collagen Type 0 achieved medialization volumes that were 40% or 100% greater than micronized human cadaveric dermis and cross-linked hyaluronic acid devices, respectively. Data also confirmed that no overt adverse reactions occurred when using Collagen Type 0 or human cadaveric dermis, whereas hyaluronic acid injections were associated with higher frequency of myocytic loss.
We are now seeking a co-development partnership to support further medical device development and to commercially launch.
The global Vocal Cord Paralysis market is estimated at $2.6 Billion in 2020 and we have identified that bulk injection laryngoscopy offers a $380 million addressable market for our developmental injectable product.
If you would like to find out more about our Vocal Cord Paralysis (VCP) or Cavity Wound Healing (CWH) projects, or have a project of your own you would like to discuss, please contact us.