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What is Collagen Type 0?

  • Collagen Type 0 is a chemically ancient, medical-grade Collagen for use in tissue engineering and regenerative medicine.
  • As it is a non-hazardous marine-derived biomaterial, it offers a safer route to regulators by being free from the risk of disease and prions.
  • Studies show that Collagen Type 0 is non-immunogenic and pro-angiogenic, pro-tissue neogenic.
  • The essential characteristics of this fibrillar collagen are identifiable using techniques such as infrared spectroscopy, circular dichroism, amino acid analysis, and electron microscopy that highlight its triple helical structure, fibril forming capabilities and stability.
  • It can be formulated into various formats including liquid, powder, films, sponges, hydrogels & bioinks for a variety of biomedical applications.

Collagen Type 0 Graphic

Rhizostoma pulmo barrel jellyfish

Where does Collagen Type 0 come from?

Jellagen's collagen is derived from the jellyfish species Rhizostoma pulmo. This unique protein predates its mammalian counterparts and, as such, has been designated as 'Collagen Type 0'.

Mammalian collagens are highly specialised and biologically complex, Collagen Type 0 however, is chemically simple, allowing greater functionality and structural versatility in various applications.

We responsibly source our raw material in UK and EU waters with optimised techniques that do not impact other marine species. An ISO 13485:2016 certified manufacturer, Jellagen produces Collagen Type 0 from its facility using proprietary processes at its main site in Cardiff, UK.

What does the data show?

Biocompatibility properties of Collagen Type 0 (in vitro)

In this in vitro study the effect of Collagen Type 0 on differentiated THP-1 cells, a type of cell associated with wound development, was evaluated. A previous study reported that collagen extracted from other jellyfish species (Nemopilema nomurai) may stimulate the secretion of pro-inflammatory cytokines (TNF-α / IL-6) (Ref- Putra A.B.D.N et. al., 2014). We therefore wanted to see if Collagen Type 0 from R. pulmo shows a similar or different effect.

Data from our study (Fig. 1) demonstrated that Collagen Type 0 did not induce secretion of NF-kB regulated cytokines TNF-α and IL-8 so does not mediate inflammation through the NF-kB pathway in dTHP-1 cells.

Inflammatory cytokine secretion

The secretion of TNF-α, together with other cytokines associated with inflammation (IL-8, IL-1β and IL-18), were evaluated in the differentiated THP-1 cells alone or when Collagen Type 0 was present. It was found that Collagen Type 0 did not induce significant changes in the secretion of pro-inflammatory cytokines (Fig. 1). Furthermore, the differentiated THP-1 cells (both alone and when Collagen Type 0 was present) were challenged with lipopolysaccharide (LPS). LPS is a major component of gram negative bacteria and is known to trigger an inflammatory immune response. Introduction of LPS led to a marked inflammatory response, but the presence of Collagen Type 0 did not alter this in any way (Fig. 2).

Key takeaway: Collagen Type 0 shows excellent biocompatibility and does not act in a proinflammatory (via Nf-KB or NLRP3 Inflammasome pathways) way in the presence of macrophages.

Fig 1 Normalized Expression

Fig 2 Normalized Expression

Benefits of Collagen Type 0

Jellagen’s collagen-based innovation addresses complex tissue engineering and regenerative medical needs, helping to shape next-generation medical treatments alongside current and future scientific research.


Compatible with a broad range of cell types and is an ideal biomaterial for tissue engineering and regenerative medicine.

Non Mammalian

Derived from jellyfish, avoiding religious and safety concerns over the use of mammalian collagen and disease transfer.


Translatable from in-vitro to in-vivo studies, due to its biocompatibility.

Structurally Intact

Proprietary extraction technique that maintains characteristic triple helix.

Ethically Derived

Raw materials are sourced ethically and environmentally consciously.


Claims and performance are verified by application-specific scientific data.